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alkhass 2022, 4(4): 1-4 |
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Amini J, Hasanramezani A. AAK1 Circular Regulates Neuronal Development by Interacting with miR-132, miR-146a and miR484. alkhass 2022; 4 (4) :1-4
URL: http://alkhass.srpub.org/article-4-162-en.html
URL: http://alkhass.srpub.org/article-4-162-en.html
Department of Biology, Faculty of Basic Sciences, University of Zabol, Zabol, Iran.
Abstract: (516 Views)
Autism Spectrum Disorders (ASDs) are neurodevelopmental disorders characterized by communication and social interaction impairment. Circular RNAs were discovered to be extremely enriched in the mammalian brain, to be highly conserved in sequence, and it has been demonstrated that circular RNAs deregulate in ASD brains. In the present study, we attempted to answer the question of which circular RNA can inhibit pathogenic ASD miRNAs. ASD miRNAs were downloaded from HMDD and three including miR-132, miR-146a and miR484 were selected. Their pathogenic role in ASD was determined experimentally. miRNAs gene targets predicted by miRDB and AAK1 were obtained as a common target gene. circular RNA origin from exons so, miRNAs could bind to their circular gene targets. AAK1 circular RNAs downloaded from circAtlas 2.0 and results blasted by NCBI BLAST. Finally, 10 circular RNA was obtained for AAK1.
Type of Study: Research |
Subject:
Molecular Biology
Received: 2022/09/15 | Revised: 2022/10/23 | Accepted: 2022/11/18 | Published: 2022/12/25
Received: 2022/09/15 | Revised: 2022/10/23 | Accepted: 2022/11/18 | Published: 2022/12/25
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